Senior Medicinal Chemist
Company: Vibliome Therapeutics
Posted on: July 8, 2019
Senior Medicinal ChemistUS-MT-BozemanJob ID: 2019-1196Type: Regular
Full-Time# of Openings: 1Category: Research & DevelopmentVibliome
Vibliome Therapeutics is seeking highly motivated synthetic and/or
medicinal chemists to advance unique kinase inhibitor leads from
our versatile scaffold platform and discovery technology. Emphasis
will be placed on analog synthesis based on
structure-based/hypothesis-driven design that simultaneous
leverages and enhances our proprietary SAR matrix discovery
- Preparation of follow-up analogs based on Vibliome's scaffold
technology that consistently move identified projects toward
drug-like candidates suitable for pre-IND animal studies and beyond
buy optimizing for potency, selectivity, physiochemical properties,
in vitro ADME/ PK using hypothesis driven design
- Use sound synthetic methods to prepare key intermediates and
small molecule inhibitors for our expanding kinase inhibitor
- Reduce ideas to practice in the lab quickly by effectively
employing a broad range of modern organic chemistry methods and
innovative synthetic transformations.
- Employ routine compound purification and compound
characterization techniques in support of company tactics and
- Synergize with the broader team by communicating results,
sharing insights, making plans and setting goals emphasizing
quality rather than quantity.
- M.S. or Ph.D. in Chemistry with a focus on synthetic organic
- 2-5years of experience in small molecule drug discovery
experience in academic, biotechnology, or pharmaceutical
- Proven track record of success in advancing programs from leads
to advanced candidates.
- Familiarity with lead compound optimization in the areas or
potency, selectivity, ADME and PK. Experience with structure-guided
design is preferred.
- Highly versed the all current medicinal chemistry
instrumentation: HPLC, LC-MS, NMR and purification systems
- Experienced using common medicinal chemistry software:
electronic notebook, structure drawing, data spreadsheet analysis;
data visualization; structure viewing; literature, chemical and
- Committed to staying current with the latest scientific
breakthroughs in the medicinal chemistry field through continued
reading of the literature and attendance of scientific
- An excellent team player with ability to communicate
synergistically with a multidisciplinary team. Highly organized
with excellent analytical, documentation, time management and
Physical Demands / Travel
The physical demands of this position are consistent with working
in a laboratory/ bench environment. Some light lifting and
maneuvering may be required.
The physical demands here are representative of those that must be
met by an employee to successfully perform the essential functions
of this job.
This position's work environment is based in a laboratory/ bench
The work environment characteristics described here are
representative of those encountered by an employee while performing
the essential functions of this job.
*To perform this job successfully, an individual must be able to
perform each roles and responsibilities satisfactorily. The
requirements listed above are representative of the knowledge,
skill, and/or ability required. Reasonable accommodations may be
made to enable individuals with disabilities to perform the
Vibliome Therapuetics provides equal employment opportunities (EEO)
to all employees and applicants for employment without regard to
religion, race, creed, color, sex, sexual orientation, alienage or
citizenship status, national origin, age, marital status,
pregnancy, disability, veteran or military status, predisposing
genetic characteristics or any other characteristic protected by
applicable federal, state or local law.
Keywords: Vibliome Therapeutics, Bozeman , Senior Medicinal Chemist, Other , Bozeman, Montana
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