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Senior Medicinal Chemist

Company: Vibliome Therapeutics
Location: Bozeman
Posted on: June 13, 2019

Job Description:

Senior Medicinal ChemistUS-MT-BozemanJob ID: 2Type: Regular Full-Time# of Openings: 1Category: Research & DevelopmentVibliome TherapueticsOverview Vibliome Therapeutics is seeking highly motivated synthetic and/or medicinal chemists to advance unique kinase inhibitor leads from our versatile scaffold platform and discovery technology. Emphasis will be placed on analog synthesis based on structure-based/hypothesis-driven design that simultaneous leverages and enhances our proprietary SAR matrix discovery engine. Responsibilities

  • Preparation of follow-up analogs based on Vibliome's scaffold technology that consistently move identified projects toward drug-like candidates suitable for pre-IND animal studies and beyond buy optimizing for potency, selectivity, physiochemical properties, in vitro ADME/ PK using hypothesis driven design principles.
  • Use sound synthetic methods to prepare key intermediates and small molecule inhibitors for our expanding kinase inhibitor library.
  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry methods and innovative synthetic transformations.
  • Employ routine compound purification and compound characterization techniques in support of company tactics and strategies.
  • Synergize with the broader team by communicating results, sharing insights, making plans and setting goals emphasizing quality rather than quantity. Qualifications
    • M.S. or Ph.D. in Chemistry with a focus on synthetic organic chemistry.
    • 2-5years of experience in small molecule drug discovery experience in academic, biotechnology, or pharmaceutical setting.
    • Proven track record of success in advancing programs from leads to advanced candidates.
    • Familiarity with lead compound optimization in the areas or potency, selectivity, ADME and PK. Experience with structure-guided design is preferred.
    • Highly versed the all current medicinal chemistry instrumentation: HPLC, LC-MS, NMR and purification systems
    • Experienced using common medicinal chemistry software: electronic notebook, structure drawing, data spreadsheet analysis; data visualization; structure viewing; literature, chemical and database searching.
    • Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences.
    • An excellent team player with ability to communicate synergistically with a multidisciplinary team. Highly organized with excellent analytical, documentation, time management and multi-tasking skills. Physical Demands / Travel The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required. The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Work Environment This position's work environment is based in a laboratory/ bench environment. The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job. *To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Vibliome Therapuetics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law. PM18

Keywords: Vibliome Therapeutics, Bozeman , Senior Medicinal Chemist, Other , Bozeman, Montana

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