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Vice President, Chemistry

Company: Vibliome Therapeutics
Location: Bozeman
Posted on: May 17, 2020

Job Description:

Vice President, ChemistryUS-MT-BozemanJob ID: 2020-1334Type: Regular Full-Time# of Openings: 1Category: Research & DevelopmentVibliome TherapueticsOverviewVibliome Therapeutics, a dynamic venture-backed biotechnology company in Bozeman, MT, is a seeking highly motivated, experienced medicinal chemist to lead its chemistry team and advance leads from its novel technology platform for kinase inhibitor discovery. Join us as we investigate new ways to achieve exquisite selectivity with small molecule kinase inhibitors to treat cancer and immune disorders. A motivated synthetic chemist is sought who is fluent in structure-guided design methods, database mining tools, and classical drug progression criteria to manage and coordinate internal and external chemistry efforts on multiple projects using a common chemistry platform. An emphasis will be placed on creative problem solving, leadership skills, strategic thinking, structure-based hypothesis-driven analog design, business strategy, and multi-dimensional SAR analysis that leverages Vibliome's unique discovery platform. Vibliome is located in Bozeman, MT, ranked number one in the US for economic strength out of 551 micropolitan areas in the US (Policom) in both 2018 and 2019. Home to a world-class research university (top 3% in 2018 by Center for World University Rankings), Bozeman has also been ranked among the Best 20 towns (Outside Magazine), the 7th most educated city in the United States (AdvisorSmith), the Top 25 ski towns in the world (National Geographic), and the top 5 best college towns for skiers (Powder Magazine). Bozeman is located next to Yellowstone National Park in the stunning Rocky Mountains of Southwest Montana. For more information on Vibliome, please see our website, .ResponsibilitiesRoles and Responsibilities of the Position*

  • Serve on the leadership team working with the CSO and other senior leaders to establish and execute Vibliome's strategic discovery research vision.
  • Analyze Vibliome's multi-dimensional SAR matrix using structure-guided methods and biological insights to identify unique lead candidates with differentiated activity profiles.
  • Design follow-up analogs based on Vibliome's scaffold technology that consistently move identified projects toward drug-like candidates suitable for pre-IND animal studies and beyond.
  • Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME and PK by coupling multi-dimensional SAR analysis with hypothesis-driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps, even with complex or ambiguous data.
  • Provide medicinal chemistry insight for new target and lead identification based on evolving science in the kinase inhibitor space.
  • Oversee the day-to-day laboratory operations, including safety, training, regulatory compliance and external chemistry resources. Implement and support processes, software and infrastructure to enable a state-of-the-art medicinal chemistry facility including electronic documentation of methods and data.
  • Supervise 4-5 internal chemists, including goal setting, performance review and regular feedback, while mentoring them on compound progression tactics and strategies and fostering growth and intellectual development.
  • Develop accurate budget and staff projections to support team goals and monitor budget-to-actual performance throughout the year.
  • Maintain the highest level of scientific rigor and professionalism within our organization
  • Share data and progress with Vibliome management on a weekly basis and the Board of Directors as required on regular basis
  • Serve as liaison with corporate partners on issues related to medicinal chemistry
  • Participate in fundraising meetings and diligence as requiredQualificationsRequired Qualifications and Background
    • Ph.D. in Chemistry with a focus on synthetic organic chemistry.
    • 15+ years of experience in small molecule drug discovery experience in an industrial biotechnology or pharmaceutical setting.
    • Comprehensive medicinal chemistry knowledge from hits to clinical candidate selection
    • Proven track record of success in advancing programs from leads to advanced candidates.
    • Extensive experience with lead compound optimization in the areas of potency, selectivity, solubility, ADME and PK.
    • Experience with all current medicinal chemistry instrumentation: HPLC, LC-MS, NMR crystallography, and purification systems
    • Expert in using common medicinal chemistry software: electronic notebook, structure drawing, data spreadsheet analysis; data visualization; structure viewing; literature, chemical and database searching. Experience with Schrodinger LiveDesign and other Schrodinger modules is preferred.
    • Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences.
    • A team player with experience communicating with a multidisciplinary team, and experience managing a team of chemists. Accountable for the medicinal chemistry activities and progress of the company. Highly organized with excellent analytical, strategy, documentation, time management and multi-tasking skills.
    • Demonstrated success in the design, medicinal chemical optimization, and formulation/delivery of small molecule therapeutics
    • Demonstrable experience with successful IND submissions or equivalent is preferred
    • Experience in venture-backed companies is strongly preferred
    • Outstanding scientific leadership, collaboration, and management skills with an integrated view of business and scientific issues
    • Excellent verbal and written communication skills. Ability to interact with staff (at all levels) productively in a fast-paced environment
    • High degree of energy, attention to detail, and a passion for delivering important new therapies to patients with devastating diseasesEqual Opportunity EmployerVibliome provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law. PM18#LI-DNI PI120270937

Keywords: Vibliome Therapeutics, Bozeman , Vice President, Chemistry, Executive , Bozeman, Montana

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